10/31/2023 0 Comments Affinity photo reviews 2020![]() ![]() The model establishes a powerful tool to continue investigating the interaction between the peripheral and central nervous systems that leads to chronic pain.Ĭancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. ![]() Unrestrained, synchronous glutamatergic activity in the primary somatosensory cortex upper lip and jaw (S1ULp–S1J) region of the somatosensory cortex drove pain phenotypes. They used the FLIT model to investigate the role that abnormal, hypersynchronous cortical activity contributed to a neuropathic pain state. In this issue of the JCI, Ding, Fischer, and co-authors developed the foramen lacerum impingement of trigeminal nerve root (FLIT) model of human trigeminal neuralgia that has improved face, construct, and predictive validities over those of current models. One reason for the failure involves the use of animal models that lack mechanistic similarity to human pain conditions, with endpoint measurements that may not reflect the human pain experience. Only three classes of pain medications have made it into clinical use in the past 60 years despite intensive efforts and the need for nonaddictive pain treatments. ![]() These findings discern a largely unexplored class of molecules and have implications for many pathologies, including cancer. GT3-INCP was regulated by estrogen and the ER and acted via the transcription factor GATA3 to regulate BC susceptibility and risk genes. The LINC00992-encoded polypeptide GT3-INCP was upregulated in ER+ BC and drove tumor growth. They identified 758 cryptic lncRNA-encoded ORFs undergoing active translation, of which 28 had potential functional and clinical relevance in ER+ BC. In this issue of the JCI, Zheng, Wei, and colleagues used an integrative functional genomic strategy to systematically identify cryptic lncRNA-encoded ORFs that play a role in estrogen receptor–positive (ER+) breast cancer (BC). While lncRNAs are mostly noncoding, recent evidence suggests that cryptic translation within some lncRNAs may produce proteins with important regulatory functions. A majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. ![]()
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